Education

Protein Atlas During Development

Annotation of mouse peripheral nervous system

The eye Expand The eye is a complex sensory organ. The wall of the eye consists of three concentric layers: the retina, the inner neural layer; the uvea, the middle vascular layer; and the corneosclera, the outer epithelial layer. Figure legend N-cadherin proteins label the cell junctions of the primordial neural cells in the retina […]

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Annotation of mouse endothelia

The skin Expand The skin, or integument, consists of two major layers: the epidermis, composed of stratified squamous epithelium that is keratinized, and the dermis, composed of connective tissue. Figure legend VE-cadherin proteins label the endothelial cell junctions of the capillaries in the dermis of the skin from a mouse embryo at E15.5. Ep, epidermis; […]

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Annotation of mouse epithelia

The skin Expand The skin, or integument, consists of two major layers: the epidermis, composed of stratified squamous epithelium that is keratinized, and the dermis, composed of connective tissue. Figure legend E-cadherin proteins label the epithelial cell junctions in the epidermis of the skin from a mouse embryo at E15.5. Ep, epidermis; De, dermis; HF, […]

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"I am really impressed with your approach. We tried multiple times previously to create monoclonal and polyclonal antibodies to claudin-2 and MLCK1. We have had limited success generating polyclonals and no success generating monoclonals. You have generated outstanding monoclonals to both. I look forward to continuing to work with you."

Jerrold R. Turner, M.D., Ph.D.

Brigham and Women’s Hospital | Harvard Medical School

"The polyclonal antibody you generated for KIAA0408 is stunning! KIAA0408 is a novel cilium molecule that has never been studied. So, clearly there will be a lot of demand for it as we have discovered a very interesting finding and the story will be published in a high impact journal. I am strongly inclined to generate monoclonal antibody for this protein too and we should think about patenting it."

Univ.-Prof. Jay Gopalakrishnan PhD

Heinrich-Heine-Universität | Universitätsklinikum Düsseldorf

"Your ARL13B antibody works beautifully!!! We’re so happy to have a cilia-specific antibody made in rat! I can send you high resolution images to be posted on your website."

Julie Craft Van De Weghe, PhD

School of Medicine | University of Washington

"The assay is a homophilic interaction mediated cell adhesion on purified protein (in this case, immobilized purified Pcdhga9 to Pcdhga9 expressed on cell surface). Compared to control, cell adhesion is reduced in the presence of Pcdhga9 monoclonal antibody supernatants!"

Divyesh Joshi, PhD

School of Medicine | Yale University

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