Anti-AVPR2 antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Vasopressin receptors are G protein coupled receptors. There are three subtypes of vasopressin receptor: AVPR1a, AVPR1b, and AVPR2. These three subtypes differ in localization, function and signal transduction mechanisms.

Vasopressin receptor subtype V2 (AVPR2) is encoded by the AVPR2 gene in human. AVPR2 receptor is of 40 kDa and consists in seven transmembrane domains. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and the collecting duct, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism.

Mutations in AVPR2 cause nephrogenic diabetes insipidus (NDI) (OMIM 304800), an inherited disease featuring excessive loss of water in the urine.