BAX (BCL2L4) antibody

Anti-BAX (BCL2L4) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Apoptosis regulator BAX, also known as Bcl2-like protein 4 (BCL2L4), is a protein that is encoded by the BAX gene in human. BAX belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cell death pathways. BAX forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. BAX can increase the opening of the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c.