Anti-CACNA1A (Cav2.1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Calcium voltage-gated channel subunit alpha 1A, also known as Cav2.1, is a P/Q voltage-dependent calcium channel that is encoded by the CACNA1A gene in human. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Cav2.1 is predominantly expressed in neuronal tissues. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2.
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