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CACNA1A (Cav2.1) antibody


Item Cat No.: 11044

Antibody: Rabbit CACNA1A (Cav2.1) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat


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Anti-CACNA1A (Cav2.1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Calcium voltage-gated channel subunit alpha 1A, also known as Cav2.1, is a P/Q voltage-dependent calcium channel that is encoded by the CACNA1A gene in human. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Cav2.1 is predominantly expressed in neuronal tissues. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (15-aa) derived from the N-terminal region of mouse Cav2.1 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 86.7% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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