CACNA1I (Cav3.3) antibody

Anti-CACNA1I (Cav3.3) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Calcium voltage-gated channel subunit alpha 1I, also known as Cav3.3, is a T-type voltage-dependent calcium channel that is encoded by the CACNA1I gene in human. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels serve pacemaking functions in both neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle cells.