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Cadherin-16 (Cdh16) antibody labeling of mouse kidney

Cadherin-16 (Cdh16) antibody labeling of mouse kidney

Cadherin-16 proteins are highly expressed in the basolateral membrane of the distal tubules in the cortex of the mouse kidney. Lotus tetragonolobus lectin (LTL) specifically labels the brush border of the proximal tubule.

Cadherin-16 in kidney medulla

Cadherin-16 proteins are expressed by the epithelium making the thin limb (arrow) and the collecting duct (arrowhead) in the medulla of the mouse kidney. v.r.: vasa recta.

Cadherin-16 (Cdh16) antibody

$155.00 – $435.00

Item Cat No.: 00116

Antibody: Rabbit Cadherin-16 (Cdh16) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

Anti-Cadherin-16 (Cdh16) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Optional Blocking Peptide

FFPE Specific Antibody

FFPE-specific recognition antibodies are made against the same epitope sequence with novel cross-linking and stabilizing technique to lock the conformational state of epitope in a folded state similar to aldehyde induced fixation.

Western Blot Specific Antibody

Western blot-specific recognition antibodies are made against the same epitope sequence with novel denaturing and stabilizing technique to prevent the natural folding of epitope in order to lock its conformation in unfolded state.

Product price: $155.00
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Anti-Cadherin-16 (Cdh16) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Cadherin-16 is a protein that is encoded by the Cdh16 gene in human. Cadherin-16 is also known as kidney specific cadherin (Ksp-cadherin). Cadherin-16 belongs to the classic cadherin protein superfamily.

The cadherin protein features an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The cadherin ectodomain plays an adhesive role whereas the intracellular domain mediates cadherin-catenin interactions.

Cadherin-16 is exclusively expressed in the kidney, where it plays a vital role in kidney development.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (18-aa) derived from the C-terminal region of mouse Cadherin-16 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 88.9% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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Brigham and Women’s Hospital | Harvard Medical School

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Univ.-Prof. Jay Gopalakrishnan PhD

Heinrich-Heine-Universität | Universitätsklinikum Düsseldorf

"Your ARL13B antibody works beautifully!!! We’re so happy to have a cilia-specific antibody made in rat! I can send you high resolution images to be posted on your website."

Julie Craft Van De Weghe, PhD

School of Medicine | University of Washington

"The assay is a homophilic interaction mediated cell adhesion on purified protein (in this case, immobilized purified Pcdhga9 to Pcdhga9 expressed on cell surface). Compared to control, cell adhesion is reduced in the presence of Pcdhga9 monoclonal antibody supernatants!"

Divyesh Joshi, PhD

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