CASPR1 (CNTNAP1 or Paranodin) antibody

Anti-CASPR1 (CNTNAP1 or Paranodin) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

CASPR1 also known as Contactin associated protein 1 (CNTNAP1), or Paranodin or Neurexin IV, is a protein that is encoded by the CNTNAP1 gene in human. CASPR1 is a member of the neurexin family of proteins. CASPR1 consists in a large extracellular domain with multiple Laminin G-like 1 motifs, a transmembrane domain and a cytoplasmic tail. CASPR1 is a membrane protein found in the neuronal cell membrane in the paranodal section of the axon in myelinated nerves, between the Nodes of Ranvier, which contains Na⁺ channels, and the juxtaparanode, which contains K⁺ channels.