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CFTR antibody

$99.00$295.00

Item Cat No.: 20403

Antibody: Rabbit CFTR Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

Clear

Anti-CFTR antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that in human is encoded by the CFTR gene. CFTR is a 168-kDa protein consisting in 12 transmembrane domains. CFTR functions as an ATP-gated chloride channel. CFTR is found in the epithelial cells of many organs including the lung, the kidney, the liver, the pancreas and the digestive tracts.

Mutations in the CFTR gene cause cystic fibrosis, which is manifested as thickened mucus in the lungs with frequent respiratory infections, and pancreatic insufficiency giving rise to malnutrition and diabetes. All disease-causing mutations in the CFTR gene are loss-of-function mutations, which lead to a blockage of the movement of salt and water into and out of cells.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (13-aa) derived from the C-terminal region of human CFTR protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C


For Research Use Only. Not for use in clinical diagnostics.

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