Anti-claudin-16 (CLDN16) (Phospho-Thr233) antibody is validated on mouse tissue and used for immunofluorescence labeling, IHC, or western blot.

Claudin-16 is a protein that is encoded by the CLDN16 gene. It belongs to the claudin protein family making the tight junction in mammalian cells. Mutations in CLDN16 gene cause a hereditary renal disease known as familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC).

The threonine residue in the PDZ binding motif (-TRV) of the carboxyl-terminus of Claudin-16 (Thr233 in mouse or rat sequence; Thr303 in human sequence (human sequence has a longer N-terminus)) protein can be phosphorylated. Once phosphorylated at this site, Claudin-16 is unable to interact with ZO-1 and thus relocated to the luminal membrane of the epithelium.