Anti-Claudin-18 (CLDN18) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Claudin-18 is a protein that is encoded by the CLDN18 gene in human. Claudin-18 belongs to the Claudin protein superfamily.

Claudins are tetraspan proteins making the tight junction. Claudins have four transmembrane domains, two extracellular loops (ECLs: ECL1 and ECL2), amino- and carboxyl-terminal cytoplasmic domains, and a short cytoplasmic motif.

Claudin-18 has two splicing isoforms: 18.a1 and 18.a2. The difference is within the ECL1 domain. CLDN18.a1 is expressed in the lung and CLDN18.a2 is expressed in the stomach. In particular, CLDN18.a2 has been implicated in gastric cancer progression. Monoclonal antibodies against CLDN18.a2 is under clinical trial to treat advanced gastric cancer.

This antibody is able to recognize both CLDN18.a1 and CLDN18.a2.