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Custom MicroRNA Inhibitor (Antagomir) Synthesis & Validation


Item Cat No.: BCFTAN

Application: MicroRNA suppression

Reactivity: In vitro & In vivo

BiCell Scientific’s microRNA inhibitor (antagomir) synthesis and validation service provides ready-to-use single-strand LNA-RNA molecules to complement and suppress microRNA molecules.

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MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. MicroRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except that microRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. In cells of humans and other mammals, microRNAs silence gene expression primarily by destabilizing the mRNA whereas siRNAs cleaving the mRNA.

BiCell Scientific’s microRNA inhibitor (antagomir) synthesis and validation service provides ready-to-use single-strand LNA-RNA molecules to complement and suppress microRNA molecules both in vitro and in vivo.

BiCell Scientific’s in vitro grade microRNA inhibitor synthesis incorporates locked nucleic acid (LNA) modification to the nucleotides of the complementary sequence to a mature microRNA. LNA can not only enhance the resistance of microRNA inhibitor to degradation by Ribonuclease H, but also form a stronger bond to mature microRNA due to its higher Tm value. In vitro transfection of microRNA inhibitor is recommended using BiCellFectamax Transfection Reagent.

BiCell Scientific’s in vivo grade microRNA inhibitor synthesis not only incorporates locked nucleic acid (LNA) modification to the inhibitor molecule, but also conjugates cholesterol to its 3′ end, which can significantly enhance the delivery of microRNA inhibitor to various extrahepatic organs such as tumors, placenta, muscles, heart and lung. In vivo transfection of microRNA inhibitor is recommended using BiCellFectamaxVivo Transfection Reagent.

Class: LNA-RNA

Strand: Single

Purification: HPLC

Stock concentration: 100 μM

Storage buffer: DEPC water

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

Additional information


In vitro, In vivo


5 nmol, 50 nmol, 250 nmol


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"I am really impressed with your approach. We tried multiple times previously to create monoclonal and polyclonal antibodies to claudin-2 and MLCK1. We have had limited success generating polyclonals and no success generating monoclonals. You have generated outstanding monoclonals to both. I look forward to continuing to work with you."

Jerrold R. Turner, M.D., Ph.D.

Brigham and Women’s Hospital | Harvard Medical School

"The polyclonal antibody you generated for KIAA0408 is stunning! KIAA0408 is a novel cilium molecule that has never been studied. So, clearly there will be a lot of demand for it as we have discovered a very interesting finding and the story will be published in a high impact journal. I am strongly inclined to generate monoclonal antibody for this protein too and we should think about patenting it."

Univ.-Prof. Jay Gopalakrishnan PhD

Heinrich-Heine-Universität | Universitätsklinikum Düsseldorf

"Your ARL13B antibody works beautifully!!! We’re so happy to have a cilia-specific antibody made in rat! I can send you high resolution images to be posted on your website."

Julie Craft Van De Weghe, PhD

School of Medicine | University of Washington

"The assay is a homophilic interaction mediated cell adhesion on purified protein (in this case, immobilized purified Pcdhga9 to Pcdhga9 expressed on cell surface). Compared to control, cell adhesion is reduced in the presence of Pcdhga9 monoclonal antibody supernatants!"

Divyesh Joshi, PhD

School of Medicine | Yale University

"The rabbit hybridoma supernatants of anti-APOBEC3 project are tested positive by ELISA, and we are very happy about it! We previously tried a company, Abclone. Their Project "A" has immune response that is <10,000 titer in antiserum, which would explain why there is no positive mAb after fusion. Their project "B" didn't have any immune response in rabbit."

Harshita B Gupta, PhD.

School of Medicine | UT Health San Antonio

"We have tested anti mouse T cell antiserum samples from both rabbits you sent to us.

They worked very well! Thank you!"

Victoria Gorbacheva, PhD.

School of Medicine | Cleveland Clinic

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