Anti-Desmocollin-2 (DSC2) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Desmocollin-2, also known as Cadherin family member 2 (CDHF2), is encoded by the DSC2 gene in human. Desmocollin-2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Desmocollins, along with the desmogleins, are found primarily in epithelial cells where they constitute the desmosomes, a type of cell junction required for cell adhesion. Desmocollins contain an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The extracellular domain mediates intercellular interactions in the desmosome whereas the intracellular domain mediates Desmocollin interaction with intermediate filaments.