Anti-ENaC alpha (Scnn1a) (C-terminus) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from mouse tissues.

The epithelial sodium channel (ENaC) comprises of three homologous subunits: alpha, beta and gamma. ENaC alpha subunit is encoded by the SCNN1A gene in human. ENaC is nonvoltage-gated, amiloride-sensitive, sodium channel that controls fluid and electrolyte transport across epithelia in many organs.

ENaC alpha subunit consists in two transmembrane domains, a large extracellular loop and two cytoplasmic ends. ENaC alpha subunit is primarily expressed by the kidney, the intestine, the lung and the skin.

Mutations in ENaC alpha subunit cause pseudohypoaldosteronism type 1 (PHA1) (OMIM 264350), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids, and Liddle syndrome (OMIM 618126), a rare hypertensive disease resulting from increased salt reabsorption in the kidney.