Anti-ENaC gamma (Scnn1g) (human) antibody is recommended for immunofluorescence labeling, IHC, or western blot of materials from human tissues.

The epithelial sodium channel (ENaC) comprises of three homologous subunits: alpha, beta and gamma. ENaC gamma subunit is encoded by the SCNN1G gene in human. ENaC is nonvoltage-gated, amiloride-sensitive, sodium channel that controls fluid and electrolyte transport across epithelia in many organs.

ENaC gamma subunit consists in two transmembrane domains, a large extracellular loop and two cytoplasmic ends. ENaC gamma subunit is primarily expressed by the kidney, the intestine, the lung and the skin.

Mutations in ENaC gamma subunit cause pseudohypoaldosteronism type 1 (PHA1) (OMIM 264350), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids, and Liddle syndrome (OMIM 618114), a rare hypertensive disease resulting from increased salt reabsorption in the kidney.

This antibody was raised against human specific epitope sequence in ENaC gamma protein, which derives from a homologous region to the validated mouse ENaC gamma epitope (Cat No.: 20343).