Anti-Frizzled-3 (FZD3) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Frizzled class receptor 3, Frizzled-3 is encoded by the FZD3 gene in human. Members of the Frizzled protein family are receptors for Wnt signaling ligands.

Frizzled-3 consists in a cysteine-rich N-terminal extracellular domain, seven transmembrane domains and a C-terminal PDZ domain binding motif.

Together with Frizzled-6, Frizzled-3 is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.