Anti-Integrin beta-7 (ITGB7) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Integrins are transmembrane proteins that facilitate cell-extracellular matrix interactions or focal adhesions. Ligands for Integrins include fibronectin, vitronectin, collagen and laminin. An integrin molecule is composed of two  protein subunits, alpha and beta. Each subunit consists in an extracellular domain, a single transmembrane domain and a cytoplasmic domain.

Integrin beta-7 protein is encoded by the ITGB7 gene in human. Integrin beta-7 protein forms dimers with alpha-4 chain and plays a role in leukocyte adhesion. Its dimerization with alpha-4 subunit forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer’s patches.