Anti-KLHL3 antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Kelch-like protein 3 (KLHL3) is encoded by the KLHL3 gene in human. KLHL3 promotes substrate ubiquitylation of bound proteins via interaction with the cullin-RING E3 ubiquitin ligase (CRL) complex.
KLHL3 mediates ubiquitylation and degradation of WNK4, thus regulating renal excretion of salt and the extracellular fluid volume. Mutations in KLHL3 cause a dominant form of pseudohypoaldosteronism type 2 (PHA-II), also known as Gordon syndrome (OMIM 614495).
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