LATS1 (WARTS or wts) antibody

Anti-LATS1 (WARTS or wts) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Large tumor suppressor kinase 1 (LATS1), also known as WARTS or wts, is encoded by the LATS1 gene in human. The N-terminal region of LATS1 binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain in LATS1 binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 is part of the Hippo signaling pathway. The Hippo signaling pathway comprises of a kinase cascade wherein MST1/2 phosphorylates and activates LATS1/2, which in turn phosphorylates but inactivates YAP and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.