MAGI2 (AIP1 or NPHS15) antibody

Anti-MAGI2 (AIP1 or NPHS15) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, also known as membrane-associated guanylate kinase inverted 2 (MAGI-2), or atrophin-1-interacting protein 1 (AIP-1) is encoded by the MAGI2 gene in human. MAGI2 serves as a scaffold for the assembly of synaptic protein complexes and is essential for development and maintenance of synapses, including receptor endocytosis and postendocytotic trafficking. MAGI2 is also part of a multiprotein complex associated with podocytes that form slit diaphragms in the renal glomerulus.

Mutations in the MAGI2 gene cause nephrotic syndrome, type 15 (OMIM #617609).