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MAGI2 (AIP1 or NPHS15) antibody


Item Cat No.: 00179

Antibody: Rat MAGI2 (AIP1 or NPHS15) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat


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Anti-MAGI2 (AIP1 or NPHS15) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, also known as membrane-associated guanylate kinase inverted 2 (MAGI-2), or atrophin-1-interacting protein 1 (AIP-1) is encoded by the MAGI2 gene in human. MAGI2 serves as a scaffold for the assembly of synaptic protein complexes and is essential for development and maintenance of synapses, including receptor endocytosis and postendocytotic trafficking. MAGI2 is also part of a multiprotein complex associated with podocytes that form slit diaphragms in the renal glomerulus.

Mutations in the MAGI2 gene cause nephrotic syndrome, type 15 (OMIM #617609).

Host/Isotype: Rat/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (17-aa) derived from the N-terminal region of human MAGI2 protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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