MBD1 antibody

Anti-MBD1 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Methyl-CpG-binding domain protein 1 is a methylated DNA binding protein that is encoded by the MBD1 gene in human. MBD1 protein consists in multiple domains: methyl-CpG-binding domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; and transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions.