MeCP2 antibody

Anti-MeCP2 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MeCP2 (methyl CpG binding protein 2) is an important reader of DNA methylation that is encoded by the MECP2 gene in human. MeCP2 recognizes and binds to 5-mC regions in methylated DNA. MeCP2 is X-linked and subject to X inactivation. MeCP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females (OMIM #312750).