MKS3 (NPHP11 or Meckelin or TMEM67) antibody labeling of mouse tissue

MKS3 (NPHP11 or Meckelin or TMEM67) antibody labeling of the trachea

MKS3 proteins are localized to the motile cilia in the pseudostratified epithelium of the mouse trachea. ZO-1 labels the tight junction.

MKS3 in the developing lung

MKS3 proteins are found in the motile cilia of the epithelium in the bronchus of the lung from an embryonic mouse at E15.5.

MKS3 in the retina

MKS3 proteins are found in the connecting cilia (primary cilia) of the photoreceptor cells in the mouse retina. IS: inner segment; ONL: outer nuclear layer.

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MKS3 (NPHP11 or Meckelin or TMEM67) antibody

Name: MKS3 (NPHP11 or Meckelin or TMEM67) antibody
SKU: 90103
Availability: InStock

$155.00 – $435.00

Item Cat No.: 90103

Antibody: Rabbit MKS3 (NPHP11 or Meckelin or TMEM67) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

Anti-MKS3 (NPHP11 or Meckelin or TMEM67) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

volume

Clear

Optional Blocking Peptide

No blocker

1 ug blocker (+$69.00)

10 ug blocker (+$119.00)

FFPE Specific Antibody

FFPE-specific recognition antibodies are made against the same epitope sequence with novel cross-linking and stabilizing technique to lock the conformational state of epitope in a folded state similar to aldehyde induced fixation.

No FFPE Specific Antibody Antibody Add-on

200 ul FFPE Specific Antibody Antibody (+$475.00)

50 ul FFPE Specific Antibody Antibody (+$195.00)

Western Blot Specific Antibody

Western blot-specific recognition antibodies are made against the same epitope sequence with novel denaturing and stabilizing technique to prevent the natural folding of epitope in order to lock its conformation in unfolded state.

No western blot add-on

200 ul Western Blot Specific Antibody (+$475.00)

50 ul Western Blot Specific Antibody (+$195.00)

Product price:	$155.00
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Anti-MKS3 (NPHP11 or Meckelin or TMEM67) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Meckel syndrome, type 3 (MKS3) or TMEM67 or Meckelin or NPHP11 is encoded by the TMEM67 gene in human. MKS3 is a membrane protein containing 6 transmembrane domains. MKS3 is localized to the primary cilium functions in centriole migration to the apical membrane and formation of the primary cilium.

Mutations in TMEM67 cause Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6) (OMIM 607361).

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (18-aa) derived from the C-terminal region of mouse MKS3 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 94.4% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

Protocol for Staining Primary Cilium (retina section)

General and Specific Protocols

Materials and reagents Expand Equipment Leica CM1950 automatic sectioning cryostat. Thermo Fisher Scientific round (12 mm diameter) cover glass (thickness No 1.5). Thermo Fisher Scientific ColorFrostTM Plus slides made of positively charge uncoated glass. Tissue-tek Expand Tissue-tek OCT 4583 compound from VWR. Tissue-tek cryomolds from VWR. Buffers Expand 0.5% paraformaldehyde in PBS NaCl 8 […]

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MKS3 (NPHP11 or Meckelin or TMEM67) antibody

Optional Blocking Peptide

FFPE Specific Antibody

Western Blot Specific Antibody

Protocol for Staining Primary Cilium (retina section)

Reviews

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