Anti-NKCC1 (Slc12a2) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent tissues.
The Na-K-Cl cotransporter type 1 (NKCC1) protein is encoded by the SLC12A2 gene in human. NKCC1 consists in 12 transmembrane domains and the stoichiometry of the transported solutes is 1Na:1K:2Cl.
NKCC1 is highly expressed in organs that secrete fluids, such as exocrine glands and choroid plexus. In addition to exocrine glands, NKCC1 is important for establishing the potassium-rich endolymph that bathes the cochlea in the inner ear.
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