Fluorophore conjugated secondary antibodies allow location studies of target proteins at subcellular to cellular levels with nanometer resolution.
The most common approach for fluorophore conjugation to secondary antibody is by succinimidyl ester derivative of fluorophores such as FITC or Alexa Fluor dyes. However, fluorophore conjugation alters the solubility of antibody molecules, rendering aggregation of secondary antibodies at subcellular levels, which significantly reduces the spatial resolution of fluorescent signals.
BiCell Scientific Inc has developed a proprietary conjugation approach that is able to maintain the solubility of fluorophore conjugated antibodies, thus minimizing the aggregation of secondary antibody molecules and improve the spatial resolution of fluorescent signals.
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