NOTCH1 antibody

Anti-NOTCH1 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands establishes an intercellular signaling pathway that plays a key role in development.

Neurogenic locus notch homolog protein 1 (Notch 1) is a type-1 transmembrane protein that is encoded by the NOTCH1 gene in human. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.