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Patched-1 (PTCH1 or PTCH) antibody labeling of mouse retina

Patched-1 (PTCH1 or PTCH) antibody labeling of mouse retina

Patched-1 proteins are found in the connecting cilia of the photoreceptor cells and in the synapses made between photoreceptor cells and bipolar cells in the OPL of the mouse retina. IS: inner segment; ONL: outer nuclear layer; OPL: outer plexiform layer; INL: inner nuclear layer.

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Patched-1 (PTCH1 or PTCH) antibody

$155.00 – $435.00

Item Cat No.: 50701

Antibody: Rabbit Patched-1 (PTCH1 or PTCH) polyclonal antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

Anti-Patched-1 (PTCH1 or PTCH) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Protein patched homolog 1 (patched-1 or PTCH1 or PTCH) is encoded by the PTCH1 gene in human. Patched-1 is a member of the patched protein family and is the receptor for sonic hedgehog , a secreted molecule implicated in embryonic development and in tumorigenesis.

Patched-1 is a transmembrane protein that suppresses the activity of smoothened in the absence of sonic hedgehog ligand. When sonic hedgehog binds to patched-1, smoothened is released to turn on the cell proliferation program.

Optional Blocking Peptide

FFPE Specific Antibody

FFPE-specific recognition antibodies are made against the same epitope sequence with novel cross-linking and stabilizing technique to lock the conformational state of epitope in a folded state similar to aldehyde induced fixation.

Western Blot Specific Antibody

Western blot-specific recognition antibodies are made against the same epitope sequence with novel denaturing and stabilizing technique to prevent the natural folding of epitope in order to lock its conformation in unfolded state.

Product price: $155.00
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Anti-Patched-1 (PTCH1 or PTCH) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Protein patched homolog 1 (patched-1 or PTCH1 or PTCH) is encoded by the PTCH1 gene in human. Patched-1 is a member of the patched protein family and is the receptor for sonic hedgehog , a secreted molecule implicated in embryonic development and in tumorigenesis.

Patched-1 is a transmembrane protein that suppresses the activity of smoothened in the absence of sonic hedgehog ligand. When sonic hedgehog binds to patched-1, suppression of smoothened is relieved, which turns on the cell proliferation program.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (19-aa) derived from the C-terminal intracellular region of mouse patched-1 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 94.7% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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"I am really impressed with your approach. We tried multiple times previously to create monoclonal and polyclonal antibodies to claudin-2 and MLCK1. We have had limited success generating polyclonals and no success generating monoclonals. You have generated outstanding monoclonals to both. I look forward to continuing to work with you."

Jerrold R. Turner, M.D., Ph.D.

Brigham and Women’s Hospital | Harvard Medical School

"The polyclonal antibody you generated for KIAA0408 is stunning! KIAA0408 is a novel cilium molecule that has never been studied. So, clearly there will be a lot of demand for it as we have discovered a very interesting finding and the story will be published in a high impact journal. I am strongly inclined to generate monoclonal antibody for this protein too and we should think about patenting it."

Univ.-Prof. Jay Gopalakrishnan PhD

Heinrich-Heine-Universität | Universitätsklinikum Düsseldorf

"Your ARL13B antibody works beautifully!!! We’re so happy to have a cilia-specific antibody made in rat! I can send you high resolution images to be posted on your website."

Julie Craft Van De Weghe, PhD

School of Medicine | University of Washington

"The assay is a homophilic interaction mediated cell adhesion on purified protein (in this case, immobilized purified Pcdhga9 to Pcdhga9 expressed on cell surface). Compared to control, cell adhesion is reduced in the presence of Pcdhga9 monoclonal antibody supernatants!"

Divyesh Joshi, PhD

School of Medicine | Yale University

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