Shop Antibodies
Patched-1 (PTCH1 or PTCH) antibody labeling of mouse retina

Patched-1 (PTCH1 or PTCH) antibody labeling of mouse retina

Patched-1 proteins are found in the connecting cilia of the photoreceptor cells and in the synapses made between photoreceptor cells and bipolar cells in the OPL of the mouse retina. IS: inner segment; ONL: outer nuclear layer; OPL: outer plexiform layer; INL: inner nuclear layer.

Best Seller

Patched-1 (PTCH1 or PTCH) antibody

$155.00 – $435.00

Item Cat No.: 50701

Antibody: Rabbit Patched-1 (PTCH1 or PTCH) polyclonal antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

Anti-Patched-1 (PTCH1 or PTCH) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Protein patched homolog 1 (patched-1 or PTCH1 or PTCH) is encoded by the PTCH1 gene in human. Patched-1 is a member of the patched protein family and is the receptor for sonic hedgehog , a secreted molecule implicated in embryonic development and in tumorigenesis.

Patched-1 is a transmembrane protein that suppresses the activity of smoothened in the absence of sonic hedgehog ligand. When sonic hedgehog binds to patched-1, smoothened is released to turn on the cell proliferation program.

Optional Blocking Peptide

Product price
Additional options total:
Order total:

Anti-Patched-1 (PTCH1 or PTCH) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Protein patched homolog 1 (patched-1 or PTCH1 or PTCH) is encoded by the PTCH1 gene in human. Patched-1 is a member of the patched protein family and is the receptor for sonic hedgehog , a secreted molecule implicated in embryonic development and in tumorigenesis.

Patched-1 is a transmembrane protein that suppresses the activity of smoothened in the absence of sonic hedgehog ligand. When sonic hedgehog binds to patched-1, suppression of smoothened is relieved, which turns on the cell proliferation program.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (19-aa) derived from the C-terminal intracellular region of mouse patched-1 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 94.7% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

Reviews

There are no reviews yet.

Be the first to review “Patched-1 (PTCH1 or PTCH) antibody”

Related products

  • DLG2 (PSD-93 or chapsyn-110) antibody labeling of mouse colon

    DLG2 (PSD-93 or chapsyn-110) antibody

    Item Cat No.: 00263

    Antibody: Rabbit DLG2 (PSD-93 or chapsyn-110) polyclonal antibody

    Concentration: 0.25 mg/ml purified IgG

    Application: Validated by immunofluorescence labeling (1:100)

    Reactivity: Human, Mouse, Rat

    Read More
  • AGTR1 (AT1) antibody labeling of mouse kidney

    AGTR1 (AT1) antibody

    Item Cat No.: 50401

    Antibody: Rabbit AGTR1 (AT1) Polyclonal Antibody

    Concentration: 0.25 mg/ml purified IgG

    Application: Validated by immunofluorescence labeling (1:100)

    Reactivity: Human, mouse, rat

    Read More
  • Protocadherin-16 (PCDH16 or DCHS1) antibody labeling of mouse retina

    Best Seller

    Protocadherin-16 (PCDH16 or DCHS1) antibody

    Item Cat No.: 50510

    Antibody: Rabbit Protocadherin-16 (PCDH16 or DCHS1) Polyclonal Antibody

    Concentration: 0.25 mg/ml purified IgG

    Application: Validated by immunofluorescence labeling (1:100)

    Reactivity: Human, mouse, rat

    Read More

"I am really impressed with your approach. We tried multiple times previously to create monoclonal and polyclonal antibodies to claudin-2 and MLCK1. We have had limited success generating polyclonals and no success generating monoclonals. You have generated outstanding monoclonals to both. I look forward to continuing to work with you."

Jerrold R. Turner, M.D., Ph.D.

Brigham and Women’s Hospital | Harvard Medical School

"The polyclonal antibody you generated for KIAA0408 is stunning! KIAA0408 is a novel cilium molecule that has never been studied. So, clearly there will be a lot of demand for it as we have discovered a very interesting finding and the story will be published in a high impact journal. I am strongly inclined to generate monoclonal antibody for this protein too and we should think about patenting it."

Univ.-Prof. Jay Gopalakrishnan PhD

Heinrich-Heine-Universität | Universitätsklinikum Düsseldorf

"Your ARL13B antibody works beautifully!!! We’re so happy to have a cilia-specific antibody made in rat! I can send you high resolution images to be posted on your website."

Julie Craft Van De Weghe, PhD

School of Medicine | University of Washington

"The assay is a homophilic interaction mediated cell adhesion on purified protein (in this case, immobilized purified Pcdhga9 to Pcdhga9 expressed on cell surface). Compared to control, cell adhesion is reduced in the presence of Pcdhga9 monoclonal antibody supernatants!"

Divyesh Joshi, PhD

School of Medicine | Yale University

I have tested the rat polyclonal IgGs to ABCD1 by immunoflourescence on cells overexpressing ABCD1. The antibodies successfully detected the protein (either untagged or tagged with GFP) at a 1:500 dilution and there was little background. The antibodies did not detect ABCD2. So this is very good news, and you may now go ahead and clone out a monoclonal!

Annette Ehrhardt, PhD

Dept. of Pediatrics | Emory University

Contact us for questions or custom requests!

Email Us