PIK3CB (PI3K-beta or p110-beta) antibody

Anti-PIK3CB (PI3K-beta or p110-beta) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositol 3-kinase (PI3K)) is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. There are 3 classes of PI3K. Class I PI3Ks catalyze the conversion of phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) into phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3). Class II and III PI3Ks are differentiated from the Class I by their structure and function. The distinct feature of Class II PI3Ks is the C-terminal C2 domain. Class III PI3Ks produce only PI(3)P from PI.

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta is an enzyme that is encoded by the PIK3CB gene in human. PIK3CB is part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection.