Polycystin-2 (PKD2) monoclonal antibody (G6 clone)

Anti-Polycystin-2 (PKD2) monoclonal antibody (G6 clone) is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Polycystin-2, also known as Transient receptor potential polycystin-2 cation channel (TRPP2), is encoded by the PKD2 gene in human. Polycystin-2 contains a N-terminal extracellular region, six transmembrane domains and a cytoplasmic C-tail. Polycystin-2 functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in a variety of epithelial cells. Polycystin-2 interacts with polycystin-1 and TRPC1.

Polycystin-2 plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 2 (ADPKD2) (OMIM 613095).