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ROMK (Kir1.1 or KCNJ1) antibody


Item Cat No.: 20201

Antibody: Rabbit ROMK (Kir1.1 or KCNJ1) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat


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Anti-ROMK (Kir1.1 or KCNJ1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

The Renal Outer Medullary Potassium channel (ROMK) is an ATP-dependent potassium channel that transport potassium across cell membrane. ROMK is also known as Kir1.1 or KCNJ1 (inwardly-rectifying potassium channel, subfamily J, member 1). ROMK is encoded by the KCNJ1 gene in human.

ROMK consists in three transmembrane domains and the pore forming motif is within the 2nd transmembrane domain. ROMK is highly expressed in the thick ascending limbs of the kidney tubules.

Mutations in ROMK cause an autosomal recessive disease known as Bartter syndrome (OMIM 600359), which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (19-aa) derived from the C-terminal region of mouse ROMK protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 84.2% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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