Smoothened (SMO or Frizzled-11 or FZD11) antibody

Anti-Smoothened (SMO or Frizzled-11 or FZD11) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Smoothened (SMO), also known as frizzled class receptor 11 (FZD11), is encoded by the SMO gene in human. Smoothened is a key transmembrane protein participating in the hedgehog signaling pathway.

Smoothened consists in seven transmembrane domains, a N-terminal extracellular domain and a C-terminal intracellular domain. Smoothened interacts with the patched protein, a receptor for hedgehog ligand proteins. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened.