SPRY2 antibody

Anti-SPRY2 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

In Drosophila, the protein Sprouty is a developmental protein involved in cell signalling. It works by inhibiting the MAPK/ERK pathway. In Drosophila, it is an antagonist of EGFR-mediated signaling in the eye. In human, it suppresses the insulin receptor and the EGFR-transduced MAPK signaling pathway, but does not inhibit the Ras-MAPK signaling pathway.

Protein sprouty homolog 2 is a protein that is encoded by the SPRY2 gene in human. SPRY2 is a negative feedback regulator of multiple receptor tyrosine kinases (RTKs) including receptors for fibroblast growth factor (FGF), epidermal growth factor (EGF), and hepatocyte growth factor (HGF). SPRY2 gene expression has been reported silenced or repressed in cancers of the breast, the liver, the lung, the prostate, and in lymphoma.