SPRY4 (HH17) antibody

Anti-SPRY4 (HH17) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

In Drosophila, the protein Sprouty is a developmental protein involved in cell signalling. It works by inhibiting the MAPK/ERK pathway. In Drosophila, it is an antagonist of EGFR-mediated signaling in the eye. In human, it suppresses the insulin receptor and the EGFR-transduced MAPK signaling pathway, but does not inhibit the Ras-MAPK signaling pathway.

Protein sprouty homolog 4 is a protein that is encoded by the SPRY4 gene in human. Nucleotide variation in the SPRY4 gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia.