Toll-like receptor 2 (TLR2 or CD282) antibody

Anti-Toll-like receptor 2 (TLR2 or CD282) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

Toll-like receptor (TLR) family proteins play a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to human and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

Toll-like receptor 2 (TLR2 or CD282) is a member of the TLR family that is encoded by the TLR2 gene in human. TLR2 is expressed on microglia, Schwann cells, monocytes, macrophages, dendritic cells, polymorphonuclear leukocytes (PMNs or PMLs), B cells (B1a, MZ B, B2), and T cells, including Tregs (CD4+CD25+ regulatory T cells).