Toll-like receptor 4 (TLR4 or CD284) antibody

Anti-Toll-like receptor 4 (TLR4 or CD284) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

Toll-like receptor (TLR) family proteins play a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to human and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

Toll-like receptor 4 (TLR4 or CD284) is a member of the TLR family that is encoded by the TLR4 gene in human. TLR4 is expressed by the myeloid cells (erythrocytes, granulocytes, macrophages) rather than the lymphoid cells (T-cells, B-cells, NK cells). Most myeloid cells also express high levels of CD14, which facilitates activation of TLR4 by LPS.