Anti-Tricellulin (MARVELD2) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent tissues.
Tricellulin belongs to a tight junction protein family of Marvel domain-containing proteins. The MARVEL [myelin and lymphocyte (MAL) and related proteins for vesicle trafficking and membrane link] domain is a tetraspan membrane structure that has originally been identified in proteins from the myelin and the lymphocytes.
Tricellulin, also known as MARVEL domain containing 2 protein, is encoded by the MARVELD2 gene in human. Tricellulin consists in four transmembrane domains, two extracellular loops (ECLs: ECL1 and ECL2), and amino- and carboxyl-terminal cytoplasmic domains. The protein structure of Tricellulin is similar to that of Occludin.
Tricellulin is localized to the tricellular tight junction of epithelium and endothelium. Tricellulin establishes epithelial barriers such as that in the organ of Corti, where the protein is required for normal hearing. Defects in this gene cause autosomal recessive deafness type 49 (DFNB49) (OMIM 610153).
