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Validated Actinin alpha-4 antibody


Item Cat No.: 00174

Antibody: Rabbit Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat


Actinin alpha-4 is encoded by the ACTN4 gene in human. Actinin alpha-4 is an actin-binding protein. In nonmuscle cells, actinin alpha-4 is concentrated along the microfilament bundles near the adherens junctions.

Actinin alpha-4 contains actin binding domain, spectrin domain and EF-hand domain.

Actinin alpha-4 is highly expressed by the glomerular podocytes. Mutations in actinin alpha-4 cause focal segmental glomerulosclerosis (FSGS) (OMIM 603278).

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (18-aa) derived from the C-terminal region of human actinin alpha-4 protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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