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Validated Claudin-18.a1 ECL antibody


Item Cat No.: 00218.1ecl

Antibody: Rat Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat


Claudin-18 is a protein that is encoded by the CLDN18 gene in human. Claudin-18 belongs to the Claudin protein superfamily.

Claudins are tetraspan proteins making the tight junction. Claudins have four transmembrane domains, two extracellular loops (ECLs: ECL1 and ECL2), amino- and carboxyl-terminal cytoplasmic domains, and a short cytoplasmic motif.

Claudin-18 has two splicing isoforms: 18.a1 and 18.a2. The difference is within the ECL1 domain. CLDN18.a1 is expressed in the lungs and CLDN18.a2 is expressed in the stomach.

This antibody specifically recognizes Claudin-18.a1 isoform. It shows no affinity to Claudin-18.a2 isoform.

Host/Isotype: Rat/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (13-aa) derived from the C-terminal region of mouse Claudin-18.a1 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 92.3% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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