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Validated Claudin-19 antibody


Item Cat No.: 00219

Antibody: Rabbit polyclonal antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, Mouse, Rat


Claudin-19 is a protein that is encoded by the CLDN19 gene. It belongs to the claudin protein family making the tight junction in mammalian cells.

Tight junctions are intercellular organelles that form continuous seals around the epithelial or the endothelial cells to prevent solutes and water from diffusing into the paracellular space.

Mutations in CLDN19 gene cause a hereditary renal disease known as familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) and ocular involvement. Claudin-19 proteins are mostly found in the thick ascending limb of the kidney, in the pigment epithelium of the retina, and in the myelin made by the Schwann cell.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (16-aa) derived from the C-terminal region of mouse Claudin-19 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 93.4% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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