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LRP2 (megalin) antibody


Item Cat No.: 31012

Antibody: Rat LRP2 (megalin) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat


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Anti-LRP2 (megalin) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Low density lipoprotein receptor-related protein 2, also known as LRP2 or megalin, is a protein that is encoded by the LRP2 gene in human. LRP2 has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind to diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the endocytosis of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones in the brush border of the proximal tubule in the kidney.

Mutations in the LRP2 gene cause Donnai-Barrow syndrome (DBS) (OMIM #222448).

Host/Isotype: Rat/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (15-aa) derived from the C-terminal cytoplasmic region of mouse LRP2 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 93.3% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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