Anti-NDCBE (Slc4a8) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Electroneutral sodium bicarbonate exchanger 1, known as NDCBE, is encoded by the SLC4A8 gene in human. NDCBE mediates electroneutral sodium- and carbonate-dependent chloride-HCO3– exchange with a Na+:HCO3– stoichiometry of 2:1. NDCBE plays a major role in pH regulation in epithelium and neuron.
NDCBE consists in 11 transmembrane domains and is highly expressed by the epithelium in the kidney and the colon. NDCBE may interact with other chloride transporters such as CFTR or pendrin.
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