Anti-Toll-like receptor 3 (TLR3 or CD283) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.
Toll-like receptor (TLR) family proteins play a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to human and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Toll-like receptor 3 (TLR3 or CD283) is a member of the TLR family that is encoded by the TLR3 gene in human. TLR3 is abundantly expressed in the placenta and the pancreas, where it is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of IRF3 and NF-κB.
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