Anti-Vimentin (VIM) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Vimentin is a structural protein of cytoskeleton that is encoded by the VIM gene in human. Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. A vimentin monomer, like all other intermediate filaments, has a central α-helical domain, capped on each end by non-helical amino (head) and carboxyl (tail) domains. Two monomers are likely co-translationally expressed in a way that facilitates their formation of a coiled-coil dimer, which is the basic subunit of vimentin assembly.
Mutations in this gene are associated with congenital cataracts in human patients.
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