Anti-Actinin alpha-4 (ACTN4) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Actinin alpha-4 is encoded by the ACTN4 gene in human. Actinin alpha-4 is an actin-binding protein. In nonmuscle cells, actinin alpha-4 is concentrated along the microfilament bundles near the adherens junctions.
Actinin alpha-4 contains actin binding domain, spectrin domain and EF-hand domain.
Actinin alpha-4 is highly expressed by the glomerular podocytes. Mutations in actinin alpha-4 cause focal segmental glomerulosclerosis (FSGS) (OMIM 603278).
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