BiCell Scientific Inc’s Biosimilar Antibodies are research-grade human biosimilar monoclonal antibodies. Each biosimilar antibody is produced using recombinant technology in bioreactors and incorporates the same variable region sequence as the original pharmaceutical substance. The Fc domain is offered in four different isotypes: IgG1, IgG2, IgG3 and IgG4.
Biosimilar antibodies make it possible to study the biological effects of a pharmaceutical substance without needing to source expensive pharmaceutical-grade therapeutics. They can be used for many research applications including functional assays, flow cytometry, ELISA, Immunohistochemistry, pharmacokinetic assays, and others.
BiCell Scientific Inc has optimized recombinant antibody production in continuous cultivation bioreactor with chemically defined, serum-free culture medium. Continuous cultivation bioreactor permits monoclonal antibody secretion rate to reach 100-150 μg/ml medium, which enables BiCell Scientific Inc to deliver biosimilar antibodies at the gram level.
BiCell Scientific has found that an equal number of light chain to heavy chain is essential for correct folding of heavy chain and secretion of antibody with thermal stability. BiCell Scientific’s recombinant antibody production service harnesses the advantageous lentiviral transduction ability to simultaneously express IgG heavy chain and light chain at a molecular ratio of 1:1 in producer cells. The resultant stably transfected cells can produce recombinant antibodies at a similar level to native B cell-myeloma fused hybridomas. The resultant recombinant antibodies undergo similar assembly and modification processes to native antibodies in the endoplasmic reticulum, that is crucial to obtain antibody preparations with low contents of aggregates.
BiCell Scientific’s Biosimilar Antibody Production Service includes BiCell Scientific’s Bioreactor Scale-up Service of Antibody Production in Hybridoma (Cat No: BCMCHY) or Bioreactor Scale-up Service of Antibody Production in HEK293 or CHO Suspension (Cat No: BCHKCO).
Reviews
There are no reviews yet.