Anti-CACNA1B (Cav2.2) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Calcium voltage-gated channel subunit alpha 1B, also known as Cav2.2, is an N-type voltage-dependent calcium channel that is encoded by the CACNA1B gene in human. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Cav2.2 is localized primarily on the nerve terminals and dendrites as well as neuroendocrine cells. In the pain pathway, Cav2.2 serves to regulate pain signals sent from the peripheral nervous system to central nervous system. The most potent and selective blockers of Cav2.2 belong to the family of conotoxins.
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