Anti-Caspase-9 (CASP9) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Caspase-9 is a cysteine-aspartic acid protease that is encoded by the CASP9 gene in human. Caspase-9 is produced as a zymogen that can then be cleaved into 35 kDa (p35) and 10 kDa (p10) subunits that become part of the active enzyme. Caspase-9 function is required for apoptosis, leading to the normal development of the central nervous system. Caspase-9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex made of cytochrome c and the apoptotic peptidase activating factor 1.
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