Anti-Integrin alpha-E (ITGAE or CD103) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent tissues.
Integrins are transmembrane proteins that facilitate cell-extracellular matrix interactions or focal adhesions. Ligands for Integrins include fibronectin, vitronectin, collagen and laminin. An integrin molecule is composed of two protein subunits, alpha and beta. Each subunit consists in an extracellular domain, a single transmembrane domain and a cytoplasmic domain.
Integrin, alpha E (ITGAE), also known as CD103, is an integrin protein that is encoded by the ITGAE gene in human. Integrin alpha-E chain binds to integrin beta 7 chain (ITGB7) to form heterodimeric integrin molecule αEβ7. Integrin alpha-E chain is expressed widely on intraepithelial lymphocyte (IEL) T cells (both αβ T cells and γδ T cells) and on some peripheral regulatory T cells (Tregs).
Reviews
There are no reviews yet.