Anti-Integrin alpha-X (ITGAX or CD11c) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent tissues.
Integrins are transmembrane proteins that facilitate cell-extracellular matrix interactions or focal adhesions. Ligands for Integrins include fibronectin, vitronectin, collagen and laminin. An integrin molecule is composed of two protein subunits, alpha and beta. Each subunit consists in an extracellular domain, a single transmembrane domain and a cytoplasmic domain.
Integrin subunit alpha X, also known as CD11c, is encoded by the ITGAX gene in human. Integrin alpha-X chain interacts with the beta-2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 integrin complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.
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