Anti-KCNA1 (Kv1.1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Potassium voltage-gated channel subfamily A member 1 (KCNA1), also known as Kv1.1, is a shaker related voltage-gated potassium channel that is encoded by the KCNA1 gene in human. Kv1.1 consists in six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is bound to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).
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