Anti-NOTCH3 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands establishes an intercellular signaling pathway that plays a key role in development.
Neurogenic locus notch homolog protein 3 (Notch 3) is a type-1 transmembrane protein that is encoded by the NOTCH3 gene in human. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
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